Furosemide

Furosemide Tablets are a powerful diuretic used to treat fluid retention (edema) in patients with congestive heart failure, liver disease, or certain kidney disorders. Each bottle of Furosemide Tablets contains 20 mg of Furosemide, which works by reducing the amount of fluid the body makes. Furosemide Tablets are also used to treat high blood pressure and to treat edema (swelling) caused by congestive heart failure, liver disease, or certain kidney disorders. Furosemide is also sometimes used to treat certain types of hyperuricemia (a condition in which the body cannot make uric acid).

The mechanism of action of Furosemide is due to the in the urine, which helps to remove excess fluid from the body. The action of Furosemide is also thought to be related to its ability to slow the metabolism of drugs such as digoxin and other antihypertensive drugs. Furosemide is usually given to patients who are unable to produce urine (e.g., diabetics) or who are at risk of developing excessive fluid retention (e.g., patients with kidney disease).

Each bottle contains 20 mg of Furosemide, which is taken orally once a day for 5 days.

How to take Furosemide

It is important that you take this medicine exactly as prescribed by your doctor. It is recommended that you drink plenty of water to keep your stomach and kidneys healthy. You should not take this medicine more often than every 3 hours.

The usual dose is 20 mg (one tablet) once a day for 5 days. If you are not sure whether you are taking this medicine or not, talk to your doctor or pharmacist. If you have not taken your prescribed dose on time, please take it as soon as you can as it will reduce the risk of side effects.

For the best possible outcome, you may require further doses, or you may need to stop taking Furosemide.

You should not drink grapefruit juice if you have been prescribed this medicine. Avoid grapefruit juice when you are taking this medicine. Grapefruit juice is not likely to interfere with the effectiveness of Furosemide Tablets. You should avoid drinking grapefruit juice while you are taking this medicine. If you are taking a blood thinner such as warfarin or clopidogrel, or if you have been taking these medicines regularly, you should use caution while you are taking Furosemide Tablets.

You should not use this medicine if you are allergic to Furosemide or any of the ingredients listed at the end of this leaflet. If you have the following conditions, you should not take this medicine:

• Kidney problems
• Liver disease
• Recent liver failure
• History of a blood clot
• History of a severe or fatal blood disorder (e.g., sickle cell anaemia, multiple myeloma, or acute leukemia)
• Problems with the heart or blood flow
• History of stroke or blood pressure problems
• Recent heart attack
• Pregnancy
• Breast feeding
• Driving or using machines
• Severe hepatic impairment
• Recent stomach ulcer
• Severe renal impairment
• An unusual or allergic reaction to Furosemide, other medicines, foods, dyes, or preservatives

Tell your doctor if you have any other medical conditions, especially if any of the following apply to you:

• Pregnancy or breast-feeding

You should stop taking Furosemide Tablets and seek medical attention immediately if you notice any signs of fluid retention (edema) in your ankles or legs. This effect can occur after standing or lying down, and you may also experience it after eating. If you notice any symptoms of fluid retention (edema) that do not go away (redness and swelling), you should immediately consult your doctor.

Furosemide Tablets Description

Furosemide Tablets contain 20 mg of Furosemide, which works by reducing the amount of fluid the body makes. Furosemide is also sometimes given to patients who are unable to produce urine.

Lasix 40 mg Tablets

Lasix 40 mg Tablets are used to treat high blood pressure and high blood volume in people with heart failure.

Furosemide 40 mg

Lasix 40 mg is a diuretic (water pill) that works by helping to remove excess fluid from the body. It should be taken as prescribed.

How Does Lasix 40mg Work?

Lasix 40mg works by:

• It blocks the action of a chemical called a “loop” in the brain, which increases the amount of urine produced. Lasix 40mg also causes the body to retain excess water by absorbing it more readily into the body. This water does not cause any physical symptoms.
• Lasix 40mg is only effective when you’re taking it as prescribed.
• Lasix 40mg will only cause more fluid to pass from your body into the lungs and the blood. Lasix 40mg is not addictive.
• You should not take Lasix 40mg if you’re pregnant. It may cause birth defects in the unborn baby if you take it during pregnancy.
• Lasix 40mg may cause low blood pressure. You should not drive, operate heavy machinery or operate dangerous machinery until you know how Lasix 40mg will work.

Side Effects

Lasix 40mg may cause some side effects. These include:

• Headache
• Dizziness
• Nausea
• Diarrhoea
• Muscle cramps
• Stomach pain
• Flushing

If any of these side effects persist or worsen, speak to your doctor.

Lasix 40mg is a diuretic (water pill) that is used to treat high blood pressure and high blood volume in people with heart failure.

Lasix 40mg can be used to treat the symptoms of heart failure such as:

• A heart attack can be fatal. It is important to exercise caution while taking Lasix 40mg, as it may cause your heart to pump too fast or to pump too much fluid into the body.
• Heart failure can be life-threatening. Your doctor may prescribe Lasix 40mg to help you get better and prevent further complications. Your doctor will discuss with you the use of Lasix 40mg during pregnancy.

If you have questions about the safety or effectiveness of Lasix 40mg, talk to your doctor before taking this medication.

See also.

Lasix 40 mg

Lasix 40mg is used to treat high blood pressure and high blood volume in people with heart failure.

• Reduce blood pressure (hypotension) and heart failure by increasing the blood flow to the heart.
• Lasix 40mg can cause low blood pressure (low blood volume). Lasix 40mg will not cause any physical symptoms.

Tablet - white to off white, flat, uncoated tablets with beveled edges, debossed ''I21A'' on one side and breakline on the other side.Therapeutic indications: Furosemide is a potent diuretic with rapid action. Furosemide tablets are indicated for:• The treatment of fluid retention associated with heart failure, including left ventricular failure, cirrhosis of the liver and renal disease, including nephrotic syndrome. • The treatment of mild to moderate hypertension when brisk diuretic response is required. Alone or in combination with other anti-hypertensive agents in the treatment of more severe cases.FeaturesNature and contents of container:• Polypropylene containers, with snap-on polythene lids, with integral tear-off security lids OR Glass bottles with screw caps with sternan faced liner: 1000, 500, 250, 100, 84, 70,54,42,28,21,15 and 14 tablets.• Blister strips (strips composed of aluminium foil and PVdC coated PVC film): 14, 15,21,28,42,56, 70 and 84 tablets. Special precautions for storage:• Container pack: Do not store above 25°C. Keep the container tightly closed.• Keep the container in the outer carton.• Bottle pack: Do not store above 25°C. Keep the bottle tightly closed. Keep the bottle in the outer carton.• Blister pack: Do not store above 25°C. Store in the original package in order to protect from light

Discussion and conclusions Our data show that our furosemide tablets are co-administered with other loop diuretics in patients with acute edema. We observed high co-administration with furosemide in these patients. High co-administration with furosemide in these patients indicates high drug metabolism. High drug metabolism was observed in the furosemide tablets in all patients, including patients who had low co-administration with other loop diuretics. These patients often required very high doses of treatment, leading to clinically relevant impairment of renal function. In addition, high co-administration of furosemide with sodium bicarbonate was observed in some patients as a direct therapy for edema.

Furosemide

Furosemide Tablets are a potent 'loop' diuretic used in the treatment of oedema resulting from cardiac insufficiency, hepatic or renal dysfunction, parasitism, or of a traumatic origin. They are most commonly used as part of the medical management of congestive heart failure and other conditions where the body is retaining too much fluid.

Furosemide Tablets are flat faced, white circular tablets with bevelled edges. They are scored with a half break line for accurate dosing.

£0.08

Furosemide Tablets 20mg are indicated for the treatment of oedema associated with cardiac insufficiency, renal dysfunction, and trauma in cats and dogs. Furosemide is the most commonly used...

Furosemide Tablets 40mg are indicated for the treatment of oedema associated with cardiac insufficiency, renal dysfunction, and trauma in cats and dogs.

Contra-indicationsDo not use in acute glomerular nephritis, in electrolyte diseases, in patients with anuria, or patients that have received excessive doses of cardiac glycosides. Because of the danger of potentiating their toxic effects do not use with aminoglycoside or cephalosporin antibiotics. Allergic reactions have been associated with use with sulphonamides.

Special WarningsThe patient may increase its water intake to compensate for the diuresis. Consideration should be given to restricting water intake if the patient's condition makes such a course appropriate.

Special PrecautionsSpecial precautions for use in animals:Prolonged dosage may on occasions justify potassium supplementation and thus monitoring for hypokalaemia should be considered, especially if the product is used in conjunction with cardiac glycosides.Special precautions to be taken by the person administering the medicinal product to animals:Wear gloves or wash hands immediately after handling tablets. In case of accidental ingestion seek medical attention and show product label and/or pack insert to the doctor.

Adverse ReactionsNone reported

Pregnancy and LactationThe safety of use in pregnancy is not well established and a careful assessment of the likely benefits and potential risks should be made. A deleterious effect on lactation is to be expected, particularly if drinking water is restricted. Furosemide passes into milk, but not to a great extent.

InteractionsPotential interactions with other drugs include ototoxicity with aminoglycosides and nephrotoxicity with cephalosporins. Use in combination with sulphonamide treatment may lead to sulphonamide allergy. There is a possibility of interaction with cardiac glycosides.

Amounts to be Administered and Administration Route5mg/KgBW, one or two times per day. For patients weighing less than 8Kg dosage with the 20mg tablet (which may be halved) is recommended. Avoid overdosage in weak and old patients.

OverdoseDehydration and electrolyte depletion may occur. Monitor and correct, as necessary. Dosage higher than that which is recommended, may cause transitory deafness. Cardiovascular side effects may be observed in weak and old patients following overdose.

Withdrawal PeriodsNone for these species.

Forincible salt and fluid dependence, for gestational age patients with depletion of their potassiumGROUND base salts disulfiram (Amneal) or receive only disulfiram (Fadoprazole) following discontinuation of respiratory depression with antacids containing sulfamethoxaban or rifampicin (Rifadin, Rimactane) following oral medication interactions with sulphonamides

Possible Side Effects

Nausea, vomiting, headache, diarrhoea, and stomach pain are common side effects. These are unlikely to occur in all patients.

References

1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 579-581.

2. Robert F. Reilley and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 682-686.

3. University of Pennsylvania. Furosemide for Accelerated Recovery of Blood Pressure Postpartum (ForBP). NIH U. S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2020] [Accessed on 12th February 2021]https://clinicaltrials.gov/ct2/show/NCT03556761

4, Maria Rosa Ballester, Eulalia Roig, Ignasi Gich, Montse Puntes, Joaquin Delgadillo, Benjamin Santos and Rosa Maria Antonijoan. Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed on 12th February 2021]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344/

5. Elara Pharmaservices Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 12th February 2021]https://www.medicines.org.uk/emc/files/pil.12129.pdf

6. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in December 2016] [Accessed on 12th February 2021]https://www.hpra.ie/img/uploaded/swedocuments/2188112. PA0126_008_002.fbf0465a-d44d-4c59-b51b-337dd8586c8e.000001Product%20Leaflet%20Approved.170215.pdf

All authors. Electronic supplementary information.